Diagnostics for autoimmune encephalitis
Standard program neural antibodies
The standard program is a panel testing for neural antibodies. It is regularly updated to incorporate the latest findings and diagnostic possibilities and covers all relevant neural antibodies for the below listed indications:
Autoimmune encephalitis, limbic encephalitis, autoimmune cerebellar syndrome, muscular hyperexcitability syndrome (Stiff person syndrome, Morvan syndrome, neuromyotonia), sleep and movement disorders in the context of autoimmune encephalitis – paraneoplastic genesis as well as without tumor association.
Tested antibodies and diagnostic methods
The standard program for neural antibodies includes the following diagnostics:
- Antibodies against surface antigens (IIF, cell based assay):
NMDAR, GAD 65, GABA-A-R, GABA-B-R, IgLON5, AMPAR1/2, DPPX, LGI1, CASPR2, mGluR5, Glycine-R, mGluR1 - Classical onconeural antibodies (immunoblot) against:
Hu, Ma2/Ta, Ri, Yo, Sox1, CV2, DNER/Tr, Zic4, Amphiphysin, Recoverin, Titin
(in case of positive findings, a confirmation by tissue based assay is sought = IIF on mouse brain) - Tissue based assay = IIF on mouse brain:
Confirmation test for onconeural antibodies, screening for neuropil antibodies, antibodies against adenylate kinase-5, ANNA3, Purkinje cells, GFAP, GAD 65, Neurexin 3-α
Sending material, counselling
The highest diagnostic reliability and validity in the standard program for neural antibodies is achieved by the testing of a CSF-serum pair. We need 1 ml serum and 1 ml CSF.
For any questions regarding antibody-requests, please contact us on the following telephone number +49 5222 8076-259 or send an E-Mail to neuroak@laborkrone.de.
For questions relating to results, diagnostics or therapeutic consequences, please take advantage of our telephone consultation hours.