Dear colleagues,

The Anti-Mullarian-hormone (AMH) is produced by women from the start of puberty by the granulosa cells of the developing follicles in the ovary. As it is only produced by the potentially maturation-able primary and secondary follicles, the serum-AMH-level correlates well with the amount of still present, maturation-able follicles. It is therefore an ideal marker for the evaluation of the functional reserve of the ovary 1. AMH is not subject to cycle-dependent fluctuations and can therefore be tested at any phase of the menstrual cycle2.

AMH can also be used for the evaluation of the reaction rate of ovarian stimulation within fertility- medical treatment.

In our laboratory, AMH analysis as of now is by the new Assay Elecsys AMH Plus by Roche Diagnostics. There are no differences in analytics compared to the previously used Elecsys-AMH test. The only difference is the slightly changed reference values.

Nevertheless, the AMH evaluation (in pmol/L) with the Elecsys AMH Plus test allows an individualized dosage of follitropin delta by Ferring as per recommendation.

Additional information can be found in the latest professional references about follitropin delta by Ferring.

Please do not hesitate to contact Dr. Juliane Fazio on tel. +49 5222 8076-207, if you have any further questions.

  1. A. de Vet, J.S. Laven, F.H. de Jong, A.P. Themmen, B.C. Fauser: “Antimullarian hormones serum levels: a putative marker for ovarian aging.” Fertil Steril 77: 357-362, 2002
  2. A. La Marca, S. Giulini, A. Tirelli, E. Bertucci, T. Marsella, S. Xella, A. Volpe: “Anti-Mullarian hormone measurement on any day of the menstrual cycle strongly predicts ovarian response in assisted reproductive technology.” Hum Reprod 22: 766-771,2007