Analysis index

1 ml serum
1 ml CSF
(please refer to the “standard program”)

serum
< 1:20

CSF
< 1:1

Anti-NMDAR encephalitis, post-herpes encephalitis, demyelinating CNS diseases (Overlap syndrome)

Request:
Is included in the “standard program”.
Autoimmune encephalitis is included,
individual requests are possible

Single request (cell-based assay) – in case of positive findings, a confirmation by tissue based assay is sought = IIF on mouse brain.

Testing is carried out daily from Mondays to Fridays

The anti-NMDAR encephalitis is a now well-characterized, specific clinical picture. It often affects young women and is often associated with the presence of ovarian teratomas. More common are non-paraneoplastic forms, especially in children. The clinical picture is characterized by a typical phased course. Initially there are psychiatric symptoms (anxiety, psychosis), ranging from seizures, confusion, memory disorders, loss of speech to mutism. This is followed by the manifestation of movement disorders and autonomous instability with hypoventilation and increasingly impaired consciousness, which often require intensive care treatment. The detection of antibodies in the cerebrospinal fluid and the appropriate clinical picture provide proof. In 14% of all patients with anti-NMDAR encephalitis, antibodies can only be detected in the CSF and not in the serum.