Aquaporin-4-autoantibodies
((Antibodies against aquaporin 4))
| Material: | 1 ml serum |
| Methods: | Ligandenassays → Immunfluoreszenzassay (IFA) | Reference range | serum CSF |
| Indication | Neuromyelitis optica (NMO), NMO-spectrum-disorders (NMOSD) |
| Please note | These antibodies are directed against the water channel aquaporin 4 on the perivascular astrocyte endfeet close to the blood-brain- and blood-CSF-barrier. They are highly sensitive and specific for NMO or NMOSD. This enables differential diagnostic distinction to multiple sclerosis, which has important therapeutic and prognostic consequences. Single request (cell-based assay) – in case of positive findings, a confirmation by tissue based assay is sought = IIF on mouse brain. Test frequency: |
| Accredited | ja |
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