Maprotiline
Material: | 1 ml serum |
Indication | Therapeutic drug monitoring |
Therapeutic range | Maprotiline: 75 – 130 µg/l > 220 µg/l toxic
Maprotiline + Desmethylmaprotiline in total: > 750 – 1000 µg/l toxic |
Please note | Maprotiline is a tetracyclic antidepressant and primarily inhibits the re-uptake of noradrenalin. Additionally, is has antihistaminergic and alpha-1 antagonistic effects. In addition to its emotionally lifting effect, it has a sedative effect, dampening effect on psychomotor functions and anxiolytic effects. The side effect spectrum is similar to the one of tricyclic antidepressants (especially sleepiness, hypotension, dry mouth etc.) |
Accredited | ja |