Analysis index

1 ml serum

Adults:

IgG1: 4,05 g/l – 10,11 g/l
IgG2: 1,69 g/l – 7,86 g/l
IgG3: 0,11 g/l – 0,85 g/l
IgG4: 0,03 g/l – 2,01 g/l

Suspicion of humoral immune defects. Recurrent bacterial upper airway and ear-nose-throat infections. Asthma, chronic-obstructive bronchitis, food allergies, diabetes mellitus, IgG-deficiency.

There is IgG-subclass-deficiency, when:

• The concentration of one or of several IgG-subclasses lies below the age-related reference range,
• at the same time the concentrations of all IgG, IgA and IgM lie within the reference range and
• T-cell-functions are normal.

An IgG-subclass-deficiency may be without clinical relevance. On the other hand, antibody response within an IgG-subclass to a specific antigen-group may be disturbed (immunological gap) despite normal IgG-subclass-concentration. IgG-subclass-deficiencies are increasingly seen in the following diseases and immune defects: Food allergies, bronchial asthma, chronic-obstructive bronchitis, infections, otitis media, H. influenzae-infections, meningitides (Neisseria), acute/recurrent respiratory tract infections, recurrent sinusitis, diabetes mellitus, Schönlein-Henoch’s purpura, Bechterew’s, Friedreich’s ataxia, IgA-deficiency, SLE (IgG2/4), ataxia telangiectasia, CVID (common variable immunodeficiency), autoimmune cytopenias.