IGFBP-3
(Insulin like growth factor binding protein 3)
| Material: | 1 ml serum |
| Methods: | Ligandenassays → Chemilumineszenz-Immunoassay (CLIA) | Reference range | Highly age dependent (see findings report) |
| Indication | Suspicion of growth hormone deficiency in children (additional determination of IGF-1 necessary) |
| Please note | Both IGF-1 and IGFBP-3, which form in the liver with the influence of growth hormone, correlate with the integrated growth hormone concentration for several days. In children, apart from the determination of the IGF-1 for the diagnosis of a growth hormone deficiency, contemporaneous taking of IGFBP-3 is necessary, as this is less dependent on age, nutritional condition and, where applicable, chronic illnesses. In the clinical presentation of stunted growth in children, decreased IGFBP-3 levels in increased or high-normal growth hormone concentration (HGH) indicate a Laron dwarfism (HGH resistance). |
| Accredited | ja |
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