IGF-1
(Insulin like growth factor 1, somatomedin C)
Material: | 1 ml serum |
Methods: | Ligandenassays → Chemilumineszenz-Immunoassay (CLIA) | Reference range | Highly age dependent (see findings report) |
Indication | Suspicion if acromegaly, growth hormone deficiency in children (additional determination of IGFBP-3 necessary), growth hormone deficiency in the context of anterior pituitary insufficiency in adults (only in connection with determination of HGH), monitoring of acromegaly treatment and screening checks during growth hormone treatment |
Please note | Both IGF-1 and IGFBP-3, which are formed in the liver with the influence of growth hormone, correlate with the integrated growth hormone concentration for several days. IGF-1 concentration, as opposed to the growth hormone (HGH), shows hardly any fluctuations and is therefore especially suitable for screening in case of acromegaly. In children, apart from the determination of the IGF-1 for the diagnosis of a growth hormone deficiency, contemporaneous taking of IGFBP-3 is necessary, as this is less dependent on age, nutritional condition and, where applicable, chronic illnesses. In the clinical presentation of macrosomia in children, decreased IGFBP-3 levels in increased or high-normal growth hormone concentration (HGH) indicate a Laron dwarfism (HGH resistance). Decreased IGF levels are found in poorly controlled diabetes mellitus, after longer periods of fasting, malabsorption, liver diseases and hypothyroidism. A growth hormone deficiency, especially in adults mostly must be confirmed by stimulation tests. |
Accredited | ja |
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