IA2-autoantibodies
(Antibodies against islet cell specific tyrosine phosphatase)
Material: | 1 ml serum | Reference range | < 10 IE/ml |
Indication | Early diagnosis of diabetes mellitus type I. Testing of first-grade relatives of type I diabetics. Differentiation of the various diabetes types. |
Please note | On suspicion of diabetes type I or in first-grade relatives of type I diabetics, the determination of at least 3 of the 4 established markers (Islet cell-, GAD-, insulin-, IA2- and zinc-transporter-8-autoantibodies) is recommended. IA2-autoantibodies are detectable in 70 % – 80 % of patients with initial manifestation of diabetes mellitus type I. The absence of antibodies however, does not rule out diabetes mellitus type I or “Late Autoimmune Diabetes of the Adult (LADA)”, but in these patients zinc-transporter-8-autoantibodies are found in approximately 30 % of cases. Determination of insulin autoantibodies (not to be confused with islet cell autoantibodies) is very much age-dependent. They can be found increased in 90 % of initial manifestation of diabetes mellitus type I in children, but only in 20 % of cases in adults. One speaks of “idiopathic diabetes mellitus type I” when a permanent, distinctive insulin deficiency is present but neither autoantibodies nor an association to particular HLADR/DQA and HLADR/DQB alleles can be found. This however is very rare and predominantly affects Asians and Africans. |
External services | ja Labor Zentrum Weser Prof. Dr. med. Schmitz Minden |
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- CA, pancreatic islet-cell antibodies
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