IA2-autoantibodies
(Antibodies against islet cell specific tyrosine phosphatase)
| Material: | 1 ml serum | Reference range | < 10 IE/ml |
| Indication | Early diagnosis of diabetes mellitus type I. Testing of first-grade relatives of type I diabetics. Differentiation of the various diabetes types. |
| Please note | On suspicion of diabetes type I or in first-grade relatives of type I diabetics, the determination of at least 3 of the 4 established markers (Islet cell-, GAD-, insulin-, IA2- and zinc-transporter-8-autoantibodies) is recommended. IA2-autoantibodies are detectable in 70 % – 80 % of patients with initial manifestation of diabetes mellitus type I. The absence of antibodies however, does not rule out diabetes mellitus type I or “Late Autoimmune Diabetes of the Adult (LADA)”, but in these patients zinc-transporter-8-autoantibodies are found in approximately 30 % of cases. Determination of insulin autoantibodies (not to be confused with islet cell autoantibodies) is very much age-dependent. They can be found increased in 90 % of initial manifestation of diabetes mellitus type I in children, but only in 20 % of cases in adults. One speaks of “idiopathic diabetes mellitus type I” when a permanent, distinctive insulin deficiency is present but neither autoantibodies nor an association to particular HLADR/DQA and HLADR/DQB alleles can be found. This however is very rare and predominantly affects Asians and Africans. |
| External services | ja Labor Zentrum Weser Prof. Dr. med. Schmitz Minden |
More Results for the letter I
- IA2-autoantibodies (IA2)
- Antibodies against islet cell specific tyrosine phosphatase
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- IgE, total (IgE)
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- Insulin like growth factor 1, somatomedin C
- IGFBP-3 (IGFBP3)
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- Imipramine (IMI)
- Immune complexes, circulating (ZIIK)
- ZIK, CIC
- Immunofixation in serum (IE)
- Immunofixation in the urine (FIXU)
- Immunoglobulins (IGGL)
- IgG in CSF
- Immunoglobulins, IgA in CSF (IGAL)
- Immunoglobulins, IgA in serum (IGA)
- Immunoglobulins, IgA in urine (IGAU)
- Immunoglobulins, IgD in serum (IGD)
- Immunoglobulins, IgE in serum (IGE)
- Immunoglobulins, IgG in serum (IGG)
- Immunoglobulins, IgG in urine (IGGU)
- Immunoglobulins, IgG-subclasses in serum (IGGSK)
- Immunoglobulins, IgM in CSF (IGML)
- Immunoglobulins, IgM in serum (IGM)
- Immunoglobulins, IgM in urine (IGMU)
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- Inhibiting substances, detection in urine, cerebrospinal fluid and sputum (INHI)
- Inhibitor detection in CSF, urine and sputum (HEMM)
- INR value (QUICK)
- International normalized ratio, Quick’s value, Quick’s test
- Insulin (INSU)
- Insulin-autoantibodies (INSUL)
- IAA
- Interleukin-1-risk allele (PRTPCR)
- Interleukin-2-receptor, soluble (INLEU2)
- sIL-2R