Holotranscobalamin
Material: | 1 ml serum |
Methods: | Ligandenassays → Chemilumineszenz-Immunoassay (CLIA) | Reference range | > 25 pmol/l |
Indication | Suspicion of vitamin B12 deficiency |
Please note | Approximately 30 % of vitamin B12 are bound to transcobalamin. Only the part of vitamin B12 bound to transcobalamin, can be absorbed by the cells. Holotranscobalamin in many studies is more sensitive in the forecast of a vitamin B12 deficiency than the evaluation of the total vitamin B12. With serum levels > 35 pmol/l, a B12 deficiency is unlikely. The diagnostic meaningfulness in patients with marked kidney insufficiency is limited, as holotranscobalamin is eliminated renally and therefore accumulates in the plasma. Total B12 is also not a reliable marker of the B12 status in patients with kidney problems. A definite diagnosis can be made retrospectively after a therapeutic decrease of methylmalonic acid concentration in the plasma is seen following B12 injections. |
Accredited | ja |
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