Histoplasmosis
(Histoplasma capsulatum)
Material: | Antibody-demonstration: 1 ml serum PCR: EDTA-blood, sputum, BAL, puncture specimen/biopsies Pathogen detection: BAL, sputum, puncture specimen/biopsies for the cultural demonstration only after previous telephone consultation |
Methods: |
Amplifikationsverfahren → Real-time-PCR Ligandenassays → Immunoblot | Criteria for evaluation | Immunoblot: as per findings report PCR: negative |
Indication | Suspicion of imported systemic mycosis |
Please note | Highly infectious dimorphic fungus, endemic in the USA (Midwest), Central- and South Amerika, Caribbean, Africa, Indonesia, Australia, individual endemic areas in Europe. Infection by inhalation of dust particles. The majority of imported histoplasmosis infections of immune competent persons are seen after visiting bat caves in endemic areas. In approximately 95 % of cases, there is a mild or inapparent course of illness. In progressive illnesses, there is tuberculosis-like infection of the lungs with fever, general feeling of illness or weakness. Disseminated forms with lethal outcome are possible.
According to TRBA 460, these are pathogens of the risk group 3. This means, there is a high risk for the laboratory personnel during cultivation (pathogen detection). Due to this, previous telephone consultation is required when requesting this test. Further information can be found here: www.rki.de |
External services | ja Robert Koch-Institut, Standort Berlin Konsiliarlabor Mykologie |
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