Herpes simplex virus infection
Material: | Antibody demonstration: 1 ml serum, 1 ml CSF (in case of CNS symptoms) PCR: Swab from blisters, -blister content, genital swab, 1 ml CSF, conjunctival swab, 1 ml serum, 5 ml EDTA-blood. Use the tube (part of swab pack) to send swab to the laboratory. |
Methods: |
Ligandenassays → Enzyme Linked Immunosorbent Assay (ELISA) Amplifikationsverfahren → Real-time-PCR | Criteria for evaluation | IgG: < 0,9 – 1,1 index IgM: < 0,9 – 1,1 index PCR: < 100 copies/ml (EDTA-blood, CSF) negative (swab) |
Indication | Local and/or generalized herpes-infections |
Clinical presentation | Type I: Initial infection usually already during childhood, mostly asymptomatic. If symptomatic: Gingivostomatitis, herpes labialis, keratoconjunctivitis, meningoencephalitis. Type II: Initial infection usually after puberty in the urogenital area. The genital herpes lesions start as erythematous papules, which then turn into blisters. After popping, they leave ulcers with an erythematous areola and grey-white exudate. |
Please note | IgM antibody increase is usually absent in case of reactivation and can generally only be expected in initial infections. |
Accredited | ja |
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