Hepatitis, autoimmune
Material: | 2 ml serum | Reference range | Please refer to findings report |
Clinical presentation | Variable clinical symptoms such as anorexia, tiredness, nausea, vomiting, bellyaches and headaches, diarrhea, hepato-splenomegaly (approximately 50 %) |
Please note | On suspicion of primary autoimmune liver disease (autoimmune hepatitis, primary biliary cirrhosis, primary sclerosing cholangitis) and following exclusion of virus hepatitis, hemochromatosis, M. Wilson or toxic-metabolic genesis, evaluation of the following autoantibodies are recommended: ANA, SMA, anti-actin, LC-1, LKM, SLA/LP, and for the differential diagnostic evaluation AMA and ANCA. A total profile decreases the risk of misinterpretation when one or several autoantibodies are present. As a variety of different pathogenetic mechanisms can be involved in the development of hepatitis, demonstration of an autoantibody should not be interpreted in an isolated manner but rather in the clinical context. The differentiation of autoimmune hepatitis into subtypes has prognostic value. Pathophysiologically, it is likely that both polymorphisms and regulatory immune defects are the basis of the clinical presentations. 30 % of patients with autoimmune hepatitis have further autoimmune diseases. In case of acute or chronic virus hepatitis, quite often autoantibodies are detected. The titer however is usually lower than the one in primary autoimmune hepatitis. Please also refer to our indications directory, section “Hepatitis, autoimmune” |
External services | ja Labor Zentrum Weser Prof. Dr. med. Schmitz Minden |
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