Hepatitis B
(HBV-DNA)
Material: | 2 ml EDTA-blood |
Methods: | Amplifikationsverfahren → Real-time-PCR | Criteria for evaluation | < 10 IU/ml (detection limit); as a rule indication for therapy: > 2000 IU/ml |
Indication | Therapy control for chronic hepatitis B after 3 – 6 and 12 weeks, then every 3 – 6 months. Estimation of infectiosity of HBV infection during pregnancy and in the medical work environment. Evaluation of infectiosity in case of isolated anti-HBc antibody demonstration and missing HBs antigen. Demonstration of an infection with pre-core mutants of the hepatitis B virus (HBe-antigen -negative form). | Mandatory reporting | ja |
Please note | Quantitative HBV-DNA demonstration in case of chronic hepatitis B infection is relevant for therapy planning and evaluation of infectiosity. An evaluation of HBV-DNA is not required for the diagnosis of acute hepatitis B. Currently, genotyping is only deemed necessary in individual cases. There are indications of a better reaction toward interferon treatment compared to that of genotype C. After an HBV-DNA increase under Lamivudin therapy, testing for YMDD-mutant presence is useful. Escape-mutants can be found in HBV-DNA and anti-HBs coexistences. They can lead to very high viremia in case of immune suppression and severe hepatitis in case of discontinuation of immune suppression. |
Accredited | ja |
More Results for the letter H
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