GOT
(ASAT)
Material: | 1 ml serum, hemolysis-free (stability of the sample at 4°C – 8°C: 7 days) |
Methods: | Spektrometrie → UV- / VIS-Photometrie | Reference range | Men: < 50 U/l Women: < 35 U/l Children: please refer to findings report |
Indication | Diseases of the liver and bile ducts |
Please note | GOT is a ubiquitous enzyme, predominantly present in the liver- and muscle cells. 30 % are dissolved in the cytoplasm and 70 % are bound to mitochondria, therefore increased activities are especially seen in necrotizing processes. The De-Ritis-Quotient GOT/GPT from the respective serum activities of GOT and GPT allows an evaluation of the severity of liver damage. Levels < 1,0 indicate a more or less minor hepatocyte damage whereas a quotient > 1,0 is highly likely for a necrotizing liver damage. Physiologically GOT is slightly elevated during pregnancy. GOT-increases as opposed to GPT are markedly less liver-specific. CAUTION: Hemolysis leads to artificially increased parameters, as GOT concentration in the erythrocytes is 15x higher than in the serum. |
Accredited | ja |
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