Calprotectin
Material: | Cherry-sized stool sample or a minimum of 1 ml liquid stools |
Methods: | Ligandenassays → Enzyme Linked Immunosorbent Assay (ELISA) | Reference range | Inconspicuous: < 50 mg/kg
|
Indication | Suspicion of inflammatory intestinal diseases Differential diagnosis of functional bowel problems, progress checks of Crohn’s disease, ulcerative colitis. |
Please note | Calprotectin is stored in the neutrophilic granulocytes. In chemotactic stimulus, i.e. as part of an inflammatory intestinal disease, the granulocytes empty the calprotectin into the bowel lumen. Clinical relevance of calprotectin determination lies especially in the differential diagnosis of chronic inflammatory bowel diseases and irritable bowel syndrome. The amount of calprotectin reflects the activity of chronic inflammatory bowel disease and is therefore especially useful for monitoring patients with such conditions (ulcerative colitis or Crohn’s). Calprotectin concentration is also increased in case of: Bowel infections (DD exclusion of infectious cause); illnesses with enhanced proliferation (i.e. adenomas, neoplasia); mucoviscidosis. |
Accredited | ja |
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