Factor-VIII-activity
Material: | 1 ml citrate plasma, frozen (Stability in citrate plasma at 4°C – 8°C: 4 hours) |
Methods: | Koagulometrie → Koagulometrie | Reference range | 50% – 150% Children: Please refer to findings report |
Indication |
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Please note | A normal PTT value does not rule out subhemophilia A. Patients with blood group 0 show lower values (between 40 % and 80 %). Guide to interpretation: > 150 %: Acute phase reaction, permanently increased activities can be a risk factor for thromboembolic event. 50 % – 150 %: normal hemostasis 25 % – 50 %: Subhemophilia A or von-Willebrand-syndrome, slightly increased risk for bleeding, minor surgery with low risk of bleeding are possible without substitution. 5 % – 25 %: mild hemophilia A or von-Willebrand-syndrome, increased bleeding tendency 1 % – 5 %: moderate hemophilia A or von-Willebrand-syndrome type 3, spontaneous bleeding possible < 1 %: severe hemophilia A, often spontaneous bleeding (especially intraarticular bleeding)
CAUTION: An acute phase reaction can disguise mild hemophilia or subhemophilia.
For differential diagnosis between hemophilia A and von-Willebrand-syndrome both the von-Willebrand-factor antigen and von-Willebrand-factor activity should be evaluated for the assessment of bleeding tendency. |
Accredited | ja |
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