Enterovirus infection
Material: | Antibody-demonstration: 1 ml serum, CSF PCR: 1 ml serum, 5 ml EDTA-blood, 1 ml CSF, swab (dry), 1 ml bronchial secretion, 1 ml bronchial lavage fluid, 1 ml sputum, 1 ml tracheal secretion, 1 ml nasopharyngeal aspirate, 1 ml stool |
Methods: |
Amplifikationsverfahren → Real-time-PCR Ligandenassays → Enzyme Linked Immunosorbent Assay (ELISA) | Criteria for evaluation | IgG: < 11 U/ml - 15 U/ml |
Indication | Summer flu, meningitis, encephalitis, myocarditis, pleurodynia |
Please note | Picornaviridae including echoviruses (31 serotypes), coxsackie viruses A (23 serotypes) and B (6 serotypes) as well as enteroviruses type 68 – 71 are captured. In small children, results of enterovirus serology of certain serotypes may be false negative due to missing cross-reactive antibodies. Clinical symptomatology of infections with enteroviruses, ECHO- or coxsackie-viruses is alike. The route of infection is fecal-orally. Approximately 60 % of infections are clinically silent. In the remaining cases, after an incubation time of 1 – 2 weeks there may be feverish pharyngitis with cold (“summer flu”), conjunctivitis and herpangina. There may also be pleurodynia (Bornholm disease), meningitis (enteroviruses are a common cause for meningitis, mainly with mild and self-limiting pathogenesis), encephalitis, myocarditis and exanthemas (hand-mouth-foot-disease). The enterovirus-PCR also covers polioviruses types 1 – 3. |
Accredited | ja |