CXCL13
Material: | 0,5 ml CSF |
Methods: | Ligandenassays → Enzyme Linked Immunosorbent Assay (ELISA) | Reference range | < 20 pg/ml – 30 pg/ml |
Indication | Suspicion of acute neuroborreliosis |
Comment | A value of > 500 pg/ml is indicative of an acute immune system stimulation and is a strong indicator of an early phase of a bacterial infection caused by borrelia or treponema. |
Please note | Monocytes and macrophages produce and secrete chemokine CXCL13 after activation by, for example, contact with a pathogen. These pathogens may be such as borrelia burgdorferi or treponema pallidum.
Due to the increased CXCL concentration, b-cells are encouraged to migrate to the according area. If for instance the CXCL increase is located in the subarachnoid spaces due to borrelia, in case of neuro borreliosis, then the b-cells migrate to the subarachnoid spaces. The b-cells can, after contact with the pathogen, differentiate into plasma cells and secrete antibodies. As a result, there is an intrathecal antibody synthesis in the CSF and consequent increased antibody indices (AI) as an indication for, in example, neuroborreliosis. In the chronological sequence, CXCL13 increases markedly in the CSF before borrelia-specific antibodies and is often seen even before development of pleocytosis. It is therefore well suitable as an early marker on suspicion of neuroborreliosis.
CXCL13 can also be increased in the context of other illnesses such as neurolues, lymph node tumors or multiple sclerosis. The evaluation of CXCL13 should therefore always be in consideration of other clinical, anamnestic and laboratory diagnostic parameters. |
Accredited | ja |
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