CK
(Creatine kinase, CK-NAC activated)
Material: | 1 ml serum, without hemolysis |
Methods: | Spektrometrie → UV- / VIS-Photometrie | Reference range | Women: < 170 U/l Men: < 190 U/l Children: please refer to findings report |
Indication | Suspicion of skeletal muscle diseases and progress monitoring of the same |
Please note | Creatine kinase (CK) is a homo- or heterodimer protein with a molecular mass of 80 kDa. The cytoplasmic forms CK-MM, CK-MB and CK-BB as well as mitochondrial CK-MiMi are isoenzymes, however only the first three have any diagnostic relevance. CK-MM is mainly present in cardiac- and skeletal muscle and is responsible for approximately 97 % of the total serum CK activity. CK-MB with the highest specific activity is present in the cardiac muscle and is released into the bloodstream in case of damage such as infarction or myocarditis; severe skeletal muscle damage can also lead to CK-MB-increases. CK-BB is present in the CNS and smooth muscle as well as vascular endothelium.
Reasons for increased CK-values: Cardiac muscle damage or skeletal muscle damage such as acute myocardial infarction, myocarditis, muscular dystrophy of the Duchenne type, dermatomyositis, polymyositis, progressive systemic sclerosis (scleroderma, PSS), trichinosis, Crush syndrome, McArdle’s syndrome, delirium tremens, McLeod syndrome, physical exertion. Toxic effects of medication such as statins (3 - 5 % of patients), fibrates, diuretics and beta-blockers. Drugs/alcohol, mainly intoxication with cocaine, heroin, amphetamines, ethanol, barbiturates, carbon monoxide, anabolics and alcohol abuse. Iatrogenic, following intramuscular injection. Other possible reasons are arterial embolism, severe destructive processes (pancreas, liver etc.), tumors, myeloproliferative illnesses, craniocerebral trauma, subarachnoid hemorrhage, pronounced hypothyroidism. In case of non-plausible persisting CK-increases, macro-CK should be considered (please refer to section “Macro enzymes”).
Severe hemolysis may lead to false-elevated method-related CK-levels due to adenylate kinase-release from the erythrocytes. |
Accredited | ja |
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