Chlamydia infections
(Chlamydia trachomatis)
Material: | Antibody detection: 1 ml serum As chlamydia only grow intracellular, there is a requirement to harvest as cell-rich material as possible. PCR: Cervical smear, urethral swab and urine. Please request collection system. Ejaculate: In sterile tube. Puncture specimen: In sterile tube. Conjunctival swab: Dry swab. Break or cut off swab tip and send it in a tube with a little sodium chloride 0,9 %. Biopsy specimen or tissue biopsies: Send tissue sample, won under sterile conditions (i.e. synovial membrane), in tube with sodium chloride 0,9 %. |
Methods: |
Ligandenassays → Immunoblot Ligandenassays → Chemilumineszenz-Immunoassay (CLIA) Amplifikationsverfahren → Real-time-PCR | Reference range | IgG: < 16 – 22 relative units/ml PCR: negative |
Indication | Suspicion of ascending genital infection, sterility, post infectious arthritis, M. Reiter, uveitis. The additional cHSP60-IgG (chlamydial heat shock protein 60) is recommended especially on suspicion of chronic infections, i.e. as part of infertility diagnostics in case of assumed chlamydia induced adnexitis. Tubular sterility and problems over the course of pregnancy (abortion, premature labor), are attributed to cHSP60 induced autoimmune reactions. |
Please note | Chlamydia trachomatis can be seen in 5 – 10 % of young, sexually active women. Infection may remain asymptomatic for a long time.
Urogenital infections (caused by serotypes D – K): Chlamydia trachomatis, next to gonococcus, is the most common pathogen of sexually transmitted diseases. Double-infections with gonococcus can occur. In women: Urethritis, cervicitis with the danger of adnexitis, salpingitis and corresponding ectopic pregnancy and secondary sterility. Approximately 5 % of pregnant women suffer from chlamydia cervicitis. Apart from premature birth and postpartal endometritis, possible complications are transmission of infection to the child and in turn neonatal conjunctivitis or pneumonia. In men: Urethritis, epididymitis, prostatitis. Most commonly however, the infection is asymptomatic. In both sexes: Reactive arthritis, sacroiliitis. Newborn and swimming pool conjunctivitis (caused by serotypes D – K), Newborn pneumonia (caused by serotypes D – K), Trachoma (caused by serotypes A, B, C): Conjunctivitis with scar formation. Cause of blindness. Lymphogranuloma venereum/inguinale (caused by serotypes L1, L2, L3): Sexually transmitted disease, primary lesion in the form of herpes-like blisters at the entry site (such as glans penis, urethra). After 2 to 3 weeks, painful inguinal lymph nodes with possible fistulization.
In Germany, women between 13 and 25 years are entitled to a yearly screening for chlamydia in the urine as a preventative measure, paid for by the medical insurances.
Please also refer to section “Sexually transmitted diseases” (indications directory) and “Maternity prevention” (analysis index) |
Accredited | ja |
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