Analysis index

1 ml serum

negative

CREST-syndrome (70 – 80 %), progressive systemic sclerosis (PSS, scleroderma, approximately 12 %), primary biliary cirrhosis (10 – 30 %), differential diagnosis in case of Raynaud-symptomatology.

Centromere antibodies are directed against 3 main antigens and nearly always react with CENP-B. Centromere antibodies are found in PSS as well as in the limited form, the CREST-syndrome. Scl-70-antibodies are usually absent in CREST-syndrome. Rarely are they detectable in the circumscribed forms of scleroderma. The detection of centromere antibodies in persons with Raynaud-syndrome indicates the early stages of CREST-syndrome. Centromere antibodies can be found years before specific scleroderma symptoms appear. In approximately half of the patients with PBC and proof of centromere-antibodies, there are demonstrable indications of scleroderma symptomatology (such as Raynaud-syndrome).

Please also refer to section “Progressive systemic sclerosis (PSS)” (Indications directory)

Labor Zentrum Weser Prof. Dr. med. Schmitz Minden