CDT
(Carbohydrate deficient transferrin, asialotransferrin)
Material: | 1 ml serum (stability in serum at 4°C – 8°C: 7 days) |
Methods: | Hochleistungsflüssigkeitschromatographie (HPLC) → Hochleistungsflüssigkeitschromatographie (HPLC) | Reference range | < 2,50 % |
Indication | Marker for chronic alcohol abuse |
Please note | After chromatographic division of the CDT-isoforms (asialo- and disialotransferrin), CDT represents the sum of asialo- and disialotransferrin. Asialotransferrin is marked by high specificity and is found in approximately 92 % of excessive alcohol abusers whereas it is absent in 95 % of cases of only slight alcohol consumption. False-positive total CDT values due to genetic transferrin variants, chronic active hepatitis or severe iron deficiency are known, whilst a manifest hemochromatosis can lead to a false-negative result. With the chromatographic division used in our laboratory, the named genetic variants, which are seen with a frequency of 0,5 - 1,0 % in the normal population, are reliably demonstrated and can usually be ruled out as influencing factors. In case of daily alcohol consumption of 50 - 80 g (equals approximately one bottle of red wine or four bottles of beer) over a period of one to two weeks, severely increased CDT-levels are found. In case of abstinence, the levels normalize with a half-life of approximately 15 days. For further confirmation and on suspicion of excessive alcohol consumption, the highly specific marker ethylglucuronid can be measured in the urine (up to 36 hours) and in the hair. Please also refer to section “alcoholism” (indications directory) |
Accredited | ja |
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