Aspergillosis
(Molds, aspergillus spp.)
| Material: | Pathogen detection: Morning sputum, bronchial secretion, bronchoscopy sample material, swabs from the auditory canal IgE-antibodies: 1 ml serum Indirect hemagglutination: 1 ml serum Antigen demonstration, external service: 1 ml serum (galactomannan) Precipitating IgG: 1 ml serum |
| Methods: |
Kulturelle Untersuchungen → aerober Atmosphäre Ligandenassays → Immunfluoreszenzassay (IFA) Ligandenassays → Enzyme Linked Immunosorbent Assay (ELISA) | Reference range | Galactomannan: < 0,5 index IHAT: < 1:320 titer Precipitating IgG: please refer to findings report |
| Indication | Suspicion of ear mycosis, aspergilloma, allergic bronchopulmonary aspergillosis (ABPA), exogenous allergic alveolitis (EAA), invasive aspergillosis |
| Please note | Aspergillus spp. are ubiquitous molds. Clinically relevant types are A. fumigatus, A. flavus, A. terreus, A. nidulans, A. niger and A. versicolor. The following symptoms are possible: Ear mycosis (otitis externa) in immunocompetent patients, pathogen proof by culture from a swab in transport medium Aspergilloma: Pulmonary manifestation in pulmonary caverns or bronchiectasis, diagnosis by imaging in combination with serology Allergic bronchopulmonary aspergillosis: Pulmonary manifestation, especially in mucoviscidosis, special IgE/IgG evaluations Exogenous allergic alveolitis caused by aspergillus spp.: Type III allergy: Precipitating IgG Invasive aspergillosis: Patients with distinctive immunodeficiency/ granulocytopenic patients, cultural pathogen detection in primary sterile materials, repeat detection in respiratory secretion, in combination with antibody demonstration and galactomannan (antigen) demonstration, limitation to the galactomannan results due to cross reactions with antibiotics (Piperacillin-Tazobactam), food components, other fungus types, amongst others. Please also refer to “molecular fungus diagnostics, multiplex PCR” |
| External services | ja MVZ Dr. Eberhard & Partner Dortmund |
| Accredited | ja |
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