ANCA, c-, p-, atypical
(anti-neutrophil cytoplasmic antibodies)
| Material: | 1 ml serum (Stability in serum at 4°C – 8°C: 7 days). Please state, if it is an urgent test request. |
| Methods: | Ligandenassays → Immunfluoreszenzassay (IFA) | Reference range | negative |
| Indication | Wegener’s granulomatosis, rapid progressive glomerulonephritis (RPG), ulcerative colitis, primary sclerosing cholangitis, Churg Strauss syndrome, microscopic polyarteritis (MPA) |
| Please note | According to the fluorescence pattern, sub-types c-ANCA (proteinase 3-antibodies), p-ANCA (myeloperoxidase-antibodies) and atypical ANCA are differentiated. c-ANCA: c-ANCA show high sensitivity (80%) and specificity to active Wegener’s disease. Without indications for disease-activity, still approximately 40 % of patients are c-ANCA-positive. False-positive c-ANCA results are occasionally seen in pneumonia, HIV and others. Target antigen of c-ANCA is proteinase 3. Results of anti-proteinase 3 evaluations with EIA show a high correlation with c-ANCA results in the IFT. It should always be followed up by proteinase 3 evaluation. ANCA-titer is well suited for therapy monitoring. High ANCA-titers point towards active disease and titer-increases can occur as early as weeks, if not months before an exacerbation of vasculitis. p-ANCA: Important target antigen of p-ANCA is myeloperoxidase (MPO). As p-ANCA can also be directed against other antigens such as lactoferrin, lysosome, elastase, cathepsin G, there is only a weak correlation to IFT- and MPO results. MPO-evaluation should always be carried out in addition to this. Prevalence of p-ANCA for microscopic polyangiitis approximately 60 %, pauci immune necrotizing glomerulonephritis 65 % – 90 %, also incidence in periarteritis nodosa and Churg-Strauss-syndrome. Atypical ANCA (atypical p-ANCA): In the immunofluorescence there is an odd cytoplasmic pattern (so-called “snow-storm pattern”). Prevalence for ulcerative colitis 60 % – 80 %, Crohn’s 5 % – 25 %, healthy persons up to 2 %. Lactoferrin and azurocidin have been identified as antigens. Atypical ANCA are also evident in 80 % of patients with primary sclerosing cholangitis. |
| External services | ja Labor Zentrum Weser Prof. Dr. med. Schmitz Minden |
More Results for the letter A
- Accompanying substances (BEGL)
- accompanying alcohols
- ACE (ACE)
- Angio-1 converting enzyme
- Acetone (ACET)
- Acetyl carnitine in the urine (ACECAC)
- Acetylcholine receptor antibodies (AchR)
- AchR antibodies
- ACTH (ACTH)
- Adrenocorticotropic hormone
- Actinomycosis (KACTI)
- Actinomyces spp. I
- Adenovirus infection (ADVK)
- Adrenal cortex autoantibodies (NNR)
- Adrenalin in plasma (ADRE)
- Aeromonas spp. (KAERO)
- Aeromonas hydrophilia, Aeromonas sobria, Aeromonas caviae
- AFP (AFP)
- Alpha-fetoprotein
- AGS genotyping (CYP21)
- Mutation analysis of the 21-hydroxylase gene on suspicion of adrenogenital syndrome
- Albumin in CSF (ALBL)
- Albumin in the serum (ALBUM)
- Albumin in urine (ALBUC)
- Alcohol in the blood (AETHS)
- Blood alcohol
- Aldosterone in serum (ALDO)
- Aldosterone/renin quotient (ARQ)
- Alkaline leukocyte phosphatase (ALP)
- (Alkaline neutrophil phosphatase = ANP)
- Alkaline phosphatase (AP)
- Alkaline phosphatase isoenzymes (APISO)
- bone AP, liver-biliary-bowel AP
- Alkaline phosphatase of the neutrophils (ALKA01)
- Alkaline placental phosphatase (APP)
- Regan isoenzyme
- Allergen specific IgE (ALLGENSPEZ IGE)
- Allergen specific IgG with type I reaction and hyposensitization (IGG TYP I)
- Allergen specific precipitating IgG antibodies in case of exogenous allergic alveolitis (ALVEO)
- Type III allergy
- Allergy diagnostics (ALLERGIE)
- Alpha galactosidase in leucocytes (AGALA)
- Alpha-1 antitrypsin in the serum (A1A)