Indications directory

(allergic granulomatous arteritis)

Clinical presentation:

CSS is likely, if a minimum of 4 of the 6 ACR criteria are apparent (specificity 99 %, sensitivity 85 %). ACR-criteria for the classification of the Churg-Straus syndrome:

1. Asthma
2. Blood-eosinophilia (> 10 %)
3. Mono- or polyneuropathy
4. Pulmonary infiltrates (transitory)
5. Changes to the paranasal sinuses
6. Histological evidence of extravascular eosinophil-accumulation in the lung or skin

Laboratory:

No specific laboratory diagnostics, however noticeable eosinophilia (> 1000 /µl in 80 % of all patients), pANCA (rarely positive), cANCA (rarely positive), RF (occasionally positive), total IgE ↑