Aplastic anemia
| Description | Diagnostic criteria: Thrombocytes < 20 x 10 3/µl, granulocytes < 0,5 x 103/µl, retikulocytes < 20 x 103/µl. Mainly of idiopathic nature, seldom medication or infections are detectable. Basic evaluations: Differential blood count (repetitions), reticulocytes, bone marrow cytology, bone marrow histology- and immunohistochemistry. Additional required evaluations: HLA- investigations of the direct family to find a bone marrow donor, infection serology (hepatitis A, B & C, HIV, CMV, HSV, VZV, EBV, parvovirus B19, candida, Aspergillus), infection focus search on suspicion of infection, drug monitoring Exclusion diagnostics: Chromosome analysis, exclusion of paroxysmal nocturnal hemoglobinuria, which can trigger aplastic anemia. |
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