Anti-phospholipid syndrome
Description | According to the Sydney-criteria a minimum of one clinical and one laboratory criteria must be met for the diagnosis of anti-phospholipid syndrome. Clinical criteria: Venous or arterial embolism (minimum of one verified), unusual localization of the vascular obliteration (i.e. mesenterial obliteration, portal vein thrombosis, Cerebral venous sinus thrombosis and others) or intrauterine fetal death, either due to preeclampsia or placental insufficiency or a minimum of 3 or more spontaneous abortions, in which chromosomal, anatomical or hormonal abnormalities have been ruled out. Laboratory criteria: Evidence of lupus anticoagulant (with DRVVT and lupus-sensitive PTT incl. confirmation test) or evidence of anti-cardiolipin antibodies >40 GPL or MPL in the standardized ELISA or evidence of beta-2-glyprotein antibodies in the standardized ELISA. Evidence of cardiolipin-IgG and IgM antibodies, beta-2-glycoprotein antibodies (serum), lupus anticoagulants (citrate plasma) |
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