Indications directory

Hypergonadotropic OI

LH, FSH increased, estradiol decreased, anti-mullarian-hormone

Please refer to sections: “Menopause, precocious menopause, primary amenorrhea”

Hypothalamic OI

LH, FSH as well as estradiol and progesterone markedly decreased or normal. Exclusion diagnostics, as nearly all hormonal dysfunctions lead to changes of the GnRH-pulsatility and therefore LH- and FSH release.

Please refer to sections “Anorexia nervosa, amenorrhea, oligomenorrhea”

Hypophyseal OI

LH, FSH decreased or within the lower reference range. Estradiol and progesterone decreased.

Please refer to sections “Amenorrhea, oligomenorrhea, anterior pituitary insufficiency (Sheehan syndrome)”

Hyperprolactinemic OI

Prolactin, LH, FSH, TSH, testosterone, DHEAS, metoclopramide-test (function test)

Please refer to sections “Hyperprolactinemia, galactorrhea, corpus luteum insufficiency, amenorrhea, oligomenorrhea, anovulation, fertility disorders”

Hyperandrogenemic OI

Stage 1:

Testosterone, SHBG, free androgen index, DHEAS, if necessary androstendion, cortisol, LH, LH, FSH, estradiol

Stage 2:

Suspicion of adrenal hyperandrogenemia:

DHEAS, 17-OH-progesterone, ACTH-test for exclusion of AGS (function test)

Please refer to sections “Adrenogenital syndrome, hyperprolactinemia”

Suspicion of Cushing syndrome:

Cortisol day profile, dexamethasone test (see function tests)

Suspicion of ovarial hyperandrogenemia:

LH, FSH, estradiol, testosterone, SHBG

Please refer to sections “Androgenisation, corpus luteum insufficiency, amenorrhea, oligomenorrhea, anovulation, fertility disorders, metabolic syndrome, hypothyroidism