Insulin-autoantibodies
(IAA)
| Material: | 1 ml serum |
| Methods: | Ligandenassays → Radioimmunoassay (RIA) | Reference range | < 0,4 U/ml |
| Indication | Early diagnosis of type 1 diabetes mellitus. Testing of first-grade relatives of type 1 diabetics, differentiation of the individual forms of diabetes. |
| Please note | We recommend the evaluation of at least 3 of the 4 well-established markers (Islet-cell-, GAD-, IA2- and zinc transporter 8-autoantibodies) if there is suspicion of type 1 diabetes as well as for first-grade relatives of type 1 diabetics. The evaluation of insulin-autoantibodies (not to be confused with islet-cell autoantibodies) is very much age-dependent. In children, they can be seen in 90 % of the first manifestations of type 1 diabetes, in adults however in only 20 % of cases. Missing autoantibodies however do not rule out type 1 diabetes mellitus nor “late autoimmune diabetes of the adult (LADA)”. In approximately 30 % of these patients, zinc transporter 8-autoantibodies can be found. One speaks of “idiopathic type 1 diabetes mellitus, when there is a permanent, severe insulin deficiency but no autoantibodies nor an association to certain HLADR/DQA- or as HLADR/DQB-alleles are detected. This is very rare however and predominantly occurs in Asians and Africans. Previously, even in patients with type 2 diabetes, autoantibody development to insulin was generally seen when using animal-insulin (such as pig-insulin). With the modern human-insulin it is also possible in few cases, however very rare when using analogue-insulins. |
| Accredited | ja |
More Results for the letter I
- IA2-autoantibodies (IA2)
- Antibodies against islet cell specific tyrosine phosphatase
- Ibuprofen (IBU)
- IgE, total (IgE)
- IGF-1 (SOMA)
- Insulin like growth factor 1, somatomedin C
- IGFBP-3 (IGFBP3)
- Insulin like growth factor binding protein 3
- Imipramine (IMI)
- Immune complexes, circulating (ZIIK)
- ZIK, CIC
- Immunofixation in serum (IE)
- Immunofixation in the urine (FIXU)
- Immunoglobulins (IGGL)
- IgG in CSF
- Immunoglobulins, IgA in CSF (IGAL)
- Immunoglobulins, IgA in serum (IGA)
- Immunoglobulins, IgA in urine (IGAU)
- Immunoglobulins, IgD in serum (IGD)
- Immunoglobulins, IgE in serum (IGE)
- Immunoglobulins, IgG in serum (IGG)
- Immunoglobulins, IgG in urine (IGGU)
- Immunoglobulins, IgG-subclasses in serum (IGGSK)
- Immunoglobulins, IgM in CSF (IGML)
- Immunoglobulins, IgM in serum (IGM)
- Immunoglobulins, IgM in urine (IGMU)
- Infectious mononucleosis (EBV)
- Pfeiffer’s disease
- Influenza virus infection (INFL)
- Influenza viruses A, B, incl. H5N1 family of orthomyxoviruses
- Inhibiting substances, detection in urine, cerebrospinal fluid and sputum (INHI)
- Inhibitor detection in CSF, urine and sputum (HEMM)
- INR value (QUICK)
- International normalized ratio, Quick’s value, Quick’s test
- Insulin (INSU)
- Insulin-autoantibodies (INSUL)
- IAA
- Interleukin-1-risk allele (PRTPCR)
- Interleukin-2-receptor, soluble (INLEU2)
- sIL-2R