Adrenal cortex autoantibodies
| Material: | 1 ml serum | Reference range | < 1:10 titer |
| Indication | Suspicion of autoimmune adrenal cortex deficiency, possibly within the context of a polyglandular autoimmune syndrome. |
| Please note | An autoimmune adrenalitis is the most common cause of adrenal cortex insufficiency. In sporadically occurring cases and within the context of polyglandular syndromes (Type 1 including APECED (autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy), type 2), autoantibodies against 21-hydroxylase can be detected in 85 % of cases if there is adrenocortical insufficiency. Thus, the absence of antibodies against 21-hydroxylase does not rule out autoimmune genesis of the adrenocortical insufficiency. On the other hand, the sole presence of autoantibodies against 21-hydroxylase without clinical symptoms of adrenocortical insufficiency may precede disease manifestation by years. The probability of disease manifestation in the presence of antibodies is at around 20 % per year. |
| External services | ja Klinisch-immunologisches Labor Dr. Stöcker |
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