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Maternity screening

Material:

8 ml whole blood and

5 ml EDTA-blood,

furthermore cervical swab

The unmistakable identification of the samples sent, with surname, first name and birth name and barcode on the sample tube is mandatory. Please also state week of pregnancy.

Methods:

Durchflusszytometrie → Durchflusszytometrie
Ligandenassays → Enzyme Linked Immunosorbent Assay (ELISA)
Amplifikationsverfahren → Real-time-PCR
Agglutinationsteste → Indirekte Hämagglutination

Reference range

Please refer to findings report.

Indication

Pregnancy

Comment

Please also refer to: Pregnancy

Please note

The KBV ((German) National health insurance federation) guidelines for serological tests and measures during pregnancy (maternity guidelines) can be found at www.g-ba.de/informationen/richtlinien/

Mandatory tests:
(Following the current maternity guidelines of the KBV)
Each pregnant woman should have the following mandatory tests at an early time (4^th to 8^th week of pregnancy)

Analysis	Time and frequency	Explanation/Please note
Blood group, if applicable with rhesus characteristics	At first medical examination, if not already known	In rhesus-negative women, an anti-D prophylaxis should be carried out in the 28^th to 30^th week of pregnancy. Women with Dweak (attenuated D-antigen) are deemed D-positive and thus do not receive anti-D prophylaxis. Contrary to the previous term Du, carriers of Dweak, both donor and receiver, are seen as rhesus-positive, as they possess a weak but complete D.
Antibody screening test for irregular antibodies	At first medical examination and between 24^th and 27^th week of pregnancy	In case of a positive antibody screening test, further tests for blood group antigens of the mother and possibly the father could be indicated.
Rubella IgG and if applicable IgM (to rule our an infection)	At first medical examination, in case of missing or not definite immune protection again between 16^th and 17^th week of pregnancy	IgG titer determination if no 2 vaccinations are documented. Control test with a second, different test system in case of borderline titers (5 IU/ml – 9,9 IU/ml)
Chlamydia trachomatis	Between 4^th and 8^th week of pregnancy, or as early as possible	PCR determination from cervical swab
Lues screening test	4^th to 8^th week of pregnancy	A positive result must be verified with additional tests (TPPA, IgG- und 19S-IgM-FTA-ABS test, RPR/VDRL test, if applicable also Immunoblot)
Small blood count	Hemoglobin concentration at determination of pregnancy, 4-weekly from the 21^st week of pregnancy and 6-8 weeks postpartum	In case of a hemoglobin concentration < 11,2 g/dl, further tests such as ferritin, folic acid, vitamin B12 are recommended in each trimester
Urine status	At first medical examination, then every 4 weeks and 6-8 weeks postpartum
Hepatitis B antigen	After the 32^nd week of pregnancy, as close to the due date as possible	Not applicable in case of proven immunity (anti-HBs)