Analysis index

1 ml serum

Therapeutic drug monitoring

30 µg/l – 80 µg/l

> 160 µg/l toxic

Mirtazapine is a tetracyclic antidepressant. It acts primarily through an antagonism at the presynaptic alpha-2 receptor and thereby enhances the noradrenergic signaling. In addition, it acts serotonergic via the 5-HT1 receptor while simultaneously inhibiting the 5-HT2 and 5-HT3 receptors. The sedative effect of mirtazapine is caused by the inhibition of the histamine H1 receptors. The side effect spectrum primarily comprises of tiredness and weight loss due to an increase in appetite, in rare cases there may be granulocytopenia.