Factor-II-mutation
(Prothrombin mutation G20210A)
| Material: | 1 ml EDTA-blood Swab from the mucosa of the inner side of the cheek (oral mucosal cells/dry swabs). A consent declaration in accordance with genetic diagnostics law is required! |
| Methods: | Amplifikationsverfahren → PCR und Sequenzierung |
| Indication | Suspicion of thrombophilia due to factor-II-mutation with increased incidence of venous thromboembolisms in the family. Stroke in patients below the age of 50. Patients after myocardial infarction. Relatives of patients with factor-II-mutation. |
| Comment | Please also refer to: Prothrombin-mutation |
| Please note | Prevalence of factor-II-mutation in the normal population is at approximately 1,7 % in Northern Europe and 3 – 5 % in Southern Europe. In patients with first time thromboembolism, prevalence is at 4 – 8 %. Thrombosis risk is increased by approximately x4,5 – 5 in factor-II-mutations of the heterozygous form. An unusual thrombosis localization associated with factor-II-mutation is the brain sinus, especially in young women who are on oral contraceptives. |
| Accredited | ja |
| Please also refer to: | Prothrombin-Mutation |
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