Digoxin
Material: | 1 ml serum Taking of blood should be at least 6 hours (better: 8 – 24 hours) after last dose. After changing the dose, blood should only be taken after 4 – 5 half-life cycles (6 – 7 days with normal liver function). |
Methods: | Ligandenassays → Enzym-Multiplied-Immunoassay (EMIT) |
Indication | Therapeutic drug monitoring |
Therapeutic range | 0,90 – 2,00 µg/l |
Please note | Digoxin belongs to a group of naturally occurring plant-based cardiac glycosides and is the 12-hydroxy analogue of digitoxin. Symptoms of intoxication are: Ventricular arrhythmias, including ventricular tachycardia, accelerated junctional rhythms, atrial tachycardia with AV-block, AV-dissociation, increase of an AV-block, anorexia, nausea, vomiting, visual problems and weakness. Reasons for too high serum concentrations: Dose too high for age group, interaction with other medication such as verapamil, amiodarone, indomethacin, renal insufficiency. Cross reactions in case of concurrent use of digitoxin < 1 %. Only a small percentage is transformed into cardio active metabolites and the considerably less effective dihydrodigoxin. Elimination mainly by renal excretion. Disruptive factors with regard to serum concentration and cardio glycoside effectiveness: Changes to the electrolyte- and acid-base-balance, renal insufficiency, malabsorption syndrome, hypo- and hyperthyrosis, drug interactions (i.e. quinidine, cholestyramine, neomycin, antacids, kaolin-pectin). |
External services | ja Labor Zentrum Weser Prof. Dr. med. Schmitz Minden |
Accredited | ja |
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