Digitoxin
Material: | 1 ml serum (Blood to be taken 8 – 24 hours after the last dose) |
Methods: | Ligandenassays → Enzym-Multiplied-Immunoassay (EMIT) |
Therapeutic range | 10 – 25 µg/l Subtoxic: 25 – 30 µg/l Toxic: > 30 µg/l |
Please note | Digitoxin belongs to a group of naturally occurring plant-based cardiac glycosides and works by inhibiting the sodium-potassium-ATPase. Due to this, the intracellular sodium-concentration increases, which causes a decrease in outflow of calcium ions from the cell and in consequence an increase of contractility. Cross reactions in case of concurrent use of digoxin up to 6 %. Elimination half-life approx. 100 hours, digitoxin shows considerably stronger protein binding than digoxin. Biotransformation is mainly extra renal. Due to interactions with other medication (i.e. phenytoin, phenylbutazone, longer-effective barbiturates, rifampicin, cyclosporine and others), it can lead to enzyme inductions, changes to protein bindings and differing half-life. Digoxin amongst others is also formed by biotransformation. |
External services | ja Labor Zentrum Weser Prof. Dr. med. Schmitz Minden |
Accredited | ja |
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