DHEAS
(Dehydroepiandrosterone-sulfate)
Material: | 1 ml serum (Stability in serum at 4°C – 8°C: 14 days) |
Methods: | Ligandenassays → Chemilumineszenz Mikropartikel Immunoassay (CMIA) | Reference range | Women: < 4,0 µg/ml Men: < 6,4 µg/ml |
Indication | Androgenisation, menstrual disorders, acne, hirsutism, suspicion of suprarenal tumor, suspicion of AGS |
Please note | Determination of the sulfate form DHEAS in comparison with DHEA has methodical advantages relating to half-life and daily rhythm. DHEA is produced nearly exclusively in the adrenal cortex, sulfation happens in the adrenal gland, liver and bowels. An increase in DHEAS in boys is a sign of puberty onset, seen approximately 2 years earlier than the increase in testosterone. A low DHEAS-value may point toward a delayed puberty. In both men and women, DHEAS-concentration decreases continuously from the age of 30 (Adrenopause). In case of DHEAS levels > 7 µg/ml, there is a suspicion of an adrenocortical tumor. Hormone-active suprarenal adenomas usually produce androstenedione and testosterone. In addition, the various forms of adrenogenital syndrome (AGS) lead to increased DHEAS levels. |
Accredited | ja |
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