Analysis index

1 ml serum

CK-BB (brain type): 0 %

CK-MB (myocardial type):

with a total activity between 15 and 500 U/l: < 3 %

with a total activity over 500 U/l: < 4 %

CK-MM (muscular type): 97 – 100 %

Macro-CK type 1: 0 %

Macro-CK type 2: 0 %

Differential diagnosis of serum CK increase, suspicion of macro-CK

CK-MM originates from skeletal muscle. It is increasingly released after muscular spasms, trauma, surgery, intramuscular injections, arterial embolism, myositis and muscle dystrophy. CK-MB is detectable in case of myocardial damage. CK-BB activity is found in ischemia of the brain and in diseases of various inner organs (gastro-intestinal tract, lungs, kidneys). In older patients, mainly women, with an incidence of approximately 3 %, macro-CK development can be seen; its pathophysiological significance is yet unknown. Macro-CK type 1 is a CK-BB IgG or CK-MM IgA immune complex with moderate total CK increase and without clinical significance. The macro-CK type 2 as an epiphenomenon is only seen in severely ill patients (tumors, liver cirrhosis etc.) and is a multimeric mitochondrial CK (CK-Mi).