Carbamazepine
| Material: | 1 ml serum, extraction before next dose is administered |
| Methods: | Hochleistungsflüssigkeitschromatographie (HPLC) → Hochleistungsflüssigkeitschromatographie (HPLC) |
| Indication | Therapeutic drug monitoring |
| Therapeutic range | 4 – 12 mg/l Cbz and Cbz-epoxide ratio in monotherapy: 7:1. In the presence of enzyme inductors (such as phenobarbital or phenytoin), the epoxide proportion increases. |
| Please note | Carbamazepine is an antiepileptic. By structure, it belongs to the tricyclic antidepressants, despite only sharing a few of the pharmacological characteristics. It inhibits rapid release of sodium-dependent action potentials in depolarized neurons by voltage-gated blockage of sodium channels. Transmission in the liver into 10,11-carbamazepine-epoxide, which has a similar effect as carbamazepine and which can accumulate under long-term treatment. The carbamazepine concentration as stated summarily includes the primary substance and the anticonvulsively working epoxide. The carbamazepine metabolism can be induced either by the substance itself or by other antiepileptics, such as diphenylhydantoin and phenobarbital. Due to the slow and incomplete resorption in the intestines, little renal secretion and strong individual differences in half-life, it is difficult to estimate carbamazepine serum concentration. It is recommended to do follow-up checks on the blood count with thrombocyte count, liver enzymes, creatinine and urine status. Most common side effects in case of overdosing: Headaches, double vision, vertigo and nausea. |
| Accredited | ja |
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