Biotin
(Vitamin H)
Material: | 1 ml serum, frozen A cooling container will be issued on request. |
Methods: | Ligandenassays → Enzyme Linked Immunosorbent Assay (ELISA) | Reference range | > 250 pg/ml |
Indication | Suspicion of biotin deficiency due to damage of the intestinal flora, in case of long-term parenteral nutrition, malabsorption, chronic alcohol abuse, as a result of long-term consumption of raw egg white (Avidin prohibits biotin absorption) and in patients with congenital (infantile or so-called “late-onset”) biotinidase deficiency. |
Please note | Vitamin H (Biotin) is an essential co-factor of carboxylases (Pyruvate carboxylase, acetyl-CoA-carboxylase, propionyl-CoA-carboxylase and methylcrotonyl-CoA-carboxylase) and plays an important role in the metabolism of gluconeogenesis, fatty acid biosynthesis and amino acid metabolism. Whilst most food products contain biotin in only low concentrations, it is still present everywhere. It is also synthetized by the intestinal commensal flora; it is however unclear if this plays a part in biotin provision. Deficiency symptoms include dry and scaly skin, hair loss, anorexia, depression, glossitis and anemia. Due to the decreased biotin recovery from metabolized proteins, the autosomal-recessive hereditary biotinidase deficiency (prevalence 1: 61.000) leads to similar symptoms, intensified by epileptic fits, ataxia, metabolic acidosis and hearing loss. Clinical penetrance varies, depending on remaining activity of biotinidase. By early oral high dose biotin supplementation of children who appear conspicuous in the newborn screening, potentially irreversible impairments can be largely prevented. |
External services | ja MVZ Dr. Eberhard & Partner Dortmund |
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