BCR-ABL fusion gene
(Philadelphia translocation/ t9 / 22)
| Material: | 3 ml EDTA-blood 2 – 3 ml EDTA bone marrow |
| Indication | Philadelphia translocation is seen in 95 % of all patients with chronic myelogenous leukemia (CML), in approximately 2 % of patients with acute myelogenous leukemia (AML) and in approximately 25 % of adults and 5 % of children with acute lymphatic leukemia (ALL). |
| Please note | The Philadelphia chromosome is formed by translocation of the abl-proto oncogene of chromosome 9 into the bcr-gene of chromosome 22, with the development of a bcr/abl fusion gene, coding a protein with tyrosine kinase activity. This protein has a proliferation inducing effect. Within the bcr-gene, breakpoints can occur in two regions: the so-called major (M-bcr) breakpoint, and the minor (m-bcr) breakpoint. In CML-patients near enough all breakpoint are of the M-bcr type, whilst ALL-patients show the M-bcr type in 50 % and m-bcr type in 50 % of the cases. |
| External services | ja MVZ Dr. Eberhard & Partner Dortmund |
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