Leptospirosis
(Leptospira interrogans)
Material: | Antibody demonstration: 2 ml serum |
Methods: |
Amplifikationsverfahren → Real-time-PCR Mikroskopie → Dunkelfeld Ligandenassays → Enzyme Linked Immunosorbent Assay (ELISA) | Reference range | IgG: < 5,0 U/ml – 9,0 U/ml |
Indication | Suspicion of leptospirosis | Mandatory reporting | ja The laboratory has to inform the health department of direct or indirect pathogen detection, stating the patient’s name. |
Please note | The most severe form of leptospirosis is the icterohemorrhagic disease (M. Weil). Incubation period 7 – 14 days. Pathogen reservoir: mainly rats (CAUTION: canal workers!), but also cattle, pigs and dogs. Source of infection: Mainly contaminated water, also blood, tissue and urine. Highly febrile biphasic clinical presentation: Phase 1 (3 – 8 days): Leptospiremia with high fever. Phase 2 (4 – 30 days): Organic manifestation with icterus, nephritis, serous meningitis, fever of unknown origin. Mild courses without liver involvement or damage are possible. Diagnostics mainly by serology, as antibodies are already evident in large concentrations at the onset of typical manifestations. Pathogen is also excreted with the urine, especially at the beginning of the disease (approximately 3rd – 7th day), thus, a corresponding PCR may be helpful. Further information can be found at www.rki.de |
External services | ja MVZ Diamedis Diagnostische Medizin Sennestadt |
Accredited | ja |
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