2017

Dear colleagues,

The Anti-Mullarian-hormone (AMH) is produced by women from the start of puberty by the granulosa cells of the developing follicles in the ovary. As it is only produced by the potentially maturation-able primary and secondary follicles, the serum-AMH-level correlates well with the amount of still present, maturation-able follicles. It is therefore an ideal marker for the evaluation of the functional reserve of the ovary ¹. AMH is not subject to cycle-dependent fluctuations and can therefore be tested at any phase of the menstrual cycle².

AMH can also be used for the evaluation of the reaction rate of ovarian stimulation within fertility- medical treatment.

In our laboratory, AMH analysis as of now is by the new Assay Elecsys AMH Plus by Roche Diagnostics. There are no differences in analytics compared to the previously used Elecsys-AMH test. The only difference is the slightly changed reference values.

Nevertheless, the AMH evaluation (in pmol/L) with the Elecsys AMH Plus test allows an individualized dosage of follitropin delta by Ferring as per recommendation.

Additional information can be found in the latest professional references about follitropin delta by Ferring.

Please do not hesitate to contact Dr. Juliane Fazio on tel. +49 5222 8076-207, if you have any further questions.

1. A. de Vet, J.S. Laven, F.H. de Jong, A.P. Themmen, B.C. Fauser: “Antimullarian hormones serum levels: a putative marker for ovarian aging.” Fertil Steril 77: 357-362, 2002
2. A. La Marca, S. Giulini, A. Tirelli, E. Bertucci, T. Marsella, S. Xella, A. Volpe: “Anti-Mullarian hormone measurement on any day of the menstrual cycle strongly predicts ovarian response in assisted reproductive technology.” Hum Reprod 22: 766-771,2007

With the iFOBT analysis (immunological fecal occult blood test), we enable you to test for occult blood in stool. For this, we use the SENTiFIT-System by Sysmex.

The hygienic handling of the samples and the precise measuring technology of the immune-turbidimetric latex determination of human hemoglobin in stool samples make analyses faster and more reliable. Compared to the Guaiac test the sensitivity and specificity is significantly improved. There is no falsification of the result due to food components such as animal blood, vitamin C or medication, hence no specific dietary recommendation to the patient is necessary.

Our iFOB test comes to you in a practical box. This contains information about sample collection, the sample tube and the “patient help for the collection of stool samples” leaflet as well as a little bag for the sample tube. The sample tube has a sticker attached to it. Please inform your patients, that they have to fill in their name, date of birth and date of sample collection. The patient can then discreetly return the filled sample tube in the envelope to your practice. In the practice, the sample tube only needs to be barcoded and then passed on to our laboratory. The sample tube can be stored at 15°C – 30°C for up to 5 days.

For patients on the German statutory medical insurance system this test can be done every two years in the context of a bowel cancer screening from the age of 50. The statutory German medical insurance also covers the iFOBT analysis for patients over 55 every two years as an alternative to colonoscopy.

Analysis is also possible as a private/self-payable (so-called IGeL) request.

Your contact in our laboratory:
Dr. Sylvia Schön Tel. +49 5222 8076-159
Stefanie Rieke Tel. +49 5222 8076-195

Yours faithfully,

Labor Krone